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New TB Vaccine in 100 Years Advances as Welcome, Gates Foundation Fund Trial

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Welcome and the Bill & Melinda Gates Foundation have announced funding, to advance a tuberculosis (TB) vaccine candidate, M72/AS01E (M72), through a Phase III clinical trial.

If proven effective, M72 could potentially become the first new vaccine to help prevent pulmonary TB, a form of active TB, in more than 100 years.

Wellcome and the Bill & Melinda Gates Foundation made the announcement at a virtual news conference on Wednesday.

The event featured Trevor Mundel, President of Global Health at the Gates Foundation; Alexander Pym, Director of Infectious Diseases at Wellcome; and Nomathamsanga Majozi, Head of Public Engagement at the Africa Health Research Institute.

The only TB vaccine in use today, Bacille Calmette-Guérin (BCG), was first given to people in 1921.

It helps protect babies and young children against severe systemic forms of TB but offers limited protection against pulmonary TB among adolescents and adults.

TB is one of the world’s deadliest diseases, killing about 4,300 people per day, mostly those living in poverty.

In 2021, an estimated 10.6 million people fell ill with TB and 1.6 million died—about 4,300 people per day.

The disease primarily affects people in low and middle income countries, and those at highest risk are often living in poverty, with poor living and working conditions and undernutrition.

Up to a quarter of the world’s population is thought to have latent TB, a condition in which a person is infected with the bacterium that causes TB but does not have any symptoms and is at risk of progressing to active TB disease.

To support the M72 Phase III clinical trial, which will cost an estimated US$550 million, Wellcome is providing up to US$150 million and the Gates Foundation will fund the remainder, about US$400 million.

The vaccine, called M72, will be given from Year 2024 to 26,000 young adults in Africa and south-east Asia who have a latent infection with the bacteria that cause TB but no symptoms.

Commenting on the efficacy, Trevor Mundel, the Head of Global Health at the Bill & Melinda Gates Foundation, said that M72 had shown much promise in preventing TB in people with latent infections, but were not ill.

This, he said, was an important segment of the population to target.

However, “clear evidence about M72’s efficacy in preventing the emergence of active pulmonary tuberculosis will take several years to emerge from trial.

“Of course we’d be happy with 90 per cent efficacy but from our modelling, 50 per cent is good enough on the assumption that the durability is at least five years.

“Most of the vaccinologists who have looked at the data have said that is likely”.

He said the trial would probably last for four to six years.

Speaking on affordability, he said making the vaccine as affordable and as accessible as possible would be very important.

Julia Gillard, Chair of the Board of Governors at Wellcome, said: “TB remains one of the world’s deadliest infectious diseases.

“The development of an affordable, accessible vaccine for adults and adolescents would be game-changing in turning the tide against TB.

“Philanthropy can be a catalyst to drive progress, as shown by this funding of the M72 vaccine as a potential new tool in preventing escalating infectious diseases to protect those most affected.

“Sustainable progress against TB and wider disease threats will depend on global collaboration, financial backing, and political will.

“By working with communities and researchers in countries with a high burden of the disease, we can get one step closer to eliminating TB as a public health threat.”

Nomathamsanqa Majozi, Head of Public Engagement at Africa Health Research Institute, said: “Despite being curable, TB remains one of the leading causes of death in South Africa.

“In the area where I live and work, more than half of all people have had, or will have TB at some points in their lives.

“The consequences are devastating, both at a personal and a community level. M72 offers us new hope for a TB-free future.’’

Alexander Pym, the Director of Infectious Disease at Wellcome, said TB was one of the biggest health challenges in the world.

“Treatment is still four to six months long. Diagnostics can still not diagnose early enough to prevent transmission.

“Added to that is the threat of latent TB.”

He said the human immune response to TB was much more complex than to an acute viral infection and this made the process of developing a TB vaccine much longer.

“The challenge is big. We need new approaches and tools,” he said.

According to Pym, a TB vaccine will really be a game-changer; there is a need for TB innovation.

Bill Gates, Co-chair of the Bill & Melinda Gates Foundation, commented in a joint statement by the organisations.

“With TB cases and deaths on the rise, the need for new tools has never been more urgent.

“Greater investment in safe and effective TB vaccines, alongside a suite of new diagnostics and treatments could transform TB care for millions of people, saving lives and lowering the burden of this devastating and costly disease.”

World Health Organisation (WHO) Director-General, Dr Tedros Adhanom Ghebreyesus, commended the support by the Gates Foundation and Wellcome to develop a new TB vaccine.

“WHO welcomes the commitments from the Bill & Melinda Gates Foundation and Wellcome to take forward development of this vaccine candidate.

“WHO will keep supporting vaccine development and access more broadly through its TB Vaccine Accelerator Council.” (NAN)

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Health

UNICEF Promotes Menstrual Hygiene for Girls

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 The United Nations Children’s Fund (UNICEF) has encouraged girls to embrace menstruation with pride and confidence, recognizing themselves as vital contributors to humanity’s sustainability.

Mrs Aderonke Akinwole, Social and Behavioural Change Specialist at UNICEF, gave the advice during an event on Wednesday organised with the Nigeria Girls’ Guild and Lagos State Primary Health Care Board.

The event was held to commemorate Menstrual Hygiene Day (MHDay) and was attended by students from both public and private schools across Lagos.

With the theme ‘Together for a Period Friendly World,’ the event aimed to raise awareness and promote dignity in menstrual hygiene.

“When a girl begins menstruation, it should be celebrated. It signifies her transition into womanhood and her ability to sustain life.

“They should be proud, and seek accurate, helpful information to remain safe, clean, and healthy during their period,” Akinwole said.

She emphasised that girls must not feel ashamed, as menstruation is a natural part of womanhood and a symbol of female dignity.

She urged the state government to increase sensitisation efforts and include menstrual hygiene education in school curricula, religious settings, and community platforms.

Akinwole also warned against stigmatisation, especially from boys, and called for boys to be educated to respect menstruation as part of girls’ lives.

“Girls should understand the menstrual cycle even before it starts. This should be part of health education in schools, churches, mosques, and communities,” she said.

She explained that girls need awareness on menstrual hygiene management and should know how to prepare for their periods in a healthy, informed way.

Mrs Honfor Adesola, Director of Education at Lagos State Primary Education Board, commended UNICEF’s support in promoting menstrual hygiene and addressing issues affecting girls.

Adesola highlighted that maintaining menstrual hygiene is vital in preventing infections and ensuring comfort throughout the menstrual cycle.

She noted that the event also helped to raise awareness about the Human Papillomavirus (HPV) vaccine available free in health centres across Lagos.

“We’re here to mark MHDay and to engage girls on HPV awareness. The state government has provided the vaccine, and sensitisation must continue,” she explained.

She encouraged girls to discuss the HPV vaccine with their parents to gain consent, ensuring protection against cervical cancer.

“The vaccine is safe, effective, and accessible in state facilities for girls aged nine to fourteen, but many have not yet been vaccinated,” she added.

Meanwhile, Ethagah Divine, Head Girl of New Estate Baptist Secondary School, Surulere, called on NGOs to provide sanitary pads for girls.

She urged more campaigns and rallies to distribute free menstrual products, like UNICEF did, to promote hygiene and dignity during menstruation.

Miss Emmanuella Azubuike, a student of the same school, expressed gratitude to UNICEF and partners for the impactful menstrual hygiene awareness event.

“This programme has expanded my knowledge on menstrual hygiene and HPV. More NGOs should support these campaigns to reach and educate more young girls,” she said. (NAN)

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Health

Soludo’s Wife Establishes Pad Banks in 300 schools

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Wife of Anambra State Governor, Dr Nonye Soludo, says she has established pad banks in 300 schools across the state as part of her pet project, Healthy Living Initiative.

Mrs Soludo disclosed this in a message in Awka on Wednesday to mark the 2025 World Menstrual Hygiene Day.

She said that the initiative was her own approach to helping school girls whose academic focus could be affected during menstruation and related emergencies.

Mrs Soludo stressed the need to provide immediate solutions for menstrual emergencies in schools, so that girls caught off guard could confidently rely on the pad banks.

“Official data say that an estimated 37 million women and girls in Nigeria are unable to afford sanitary pads and only rely on unhygienic alternatives.

“The data reinforce World Health Organisation and United Nations Children’s Fund finding that poor water, sanitation and hygiene infrastructure hinders safe and dignified menstruation for women and girls.

“Other data say that only two in five schools globally offer menstrual health education and just one in three have bins for menstrual waste.

“These figures challenge key stakeholders to find practical solutions to address the root of the problem while the situation remains reversible.”

She called for intensified campaign to reach more women and girls currently facing menstrual hygiene challenges.

The governor’s wife noted that the growing number of women, especially girls, in urgent need of menstrual support makes it essential for stakeholders to re-strategise their campaign approach.

According to her, menstrual health remains the right of every girl-child.

She encouraged girls at the designated schools participating in the pad bank project to use the supplies with confidence.

Mrs Soludo assured them that her NGO was fully committed to restocking any of the pad banks that run out of sanitary products.(NAN)

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General News

More Recognitions, Honor for Ogbodo, Receives Peace Ambassador, Ministerial Award for Outstanding Service

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By David Torough, Abuja

Medical Director of Lydia Memorial Hospital in Okpokwu, Benue State, Dr. Mark Ogbodo has once again been honored for his exceptional service to humanity.

This time receiving the prestigious title of Peace Ambassador and a Ministerial Award for the Most Dedicated, Committed and Hardworking Hospital in Benue State.

The honours were bestowed by the National Association of Nigerian Youths Ambassadors for Peace Initiative (NANYAPI) in recognition of Dr.

Ogbodo’s bravery, dedication, and unwavering commitment to medical service delivery in Okpokwu Local Government Area, Benue State, and Nigeria at large.

Presenting the award, the President of NANYAPI, Comrade Aji Abraham, described Dr.

Ogbodo as a role model whose leadership and selfless service have distinguished him as a beacon of peace and a symbol of hope. He commended Dr. Ogbodo’s outstanding managerial skills and humanitarian spirit, which he said inspired the association to honour him.

The event, held at Lydia Memorial Hospital, drew friends, well-wishers, and dignitaries from various sectors. In a welcome address on behalf of the hospital’s management and staff, Miss Victory Oche expressed heartfelt appreciation for the presence of the association’s leadership and delegates, as well as supporters of Dr. Ogbodo.

“May our purpose of gathering here today, which is to celebrate and honour our mentor and leader, Dr. Mark A. C. Ogbodo, for his unwavering and relentless contributions to humanity and nation building, be fruitful,” she said.

In his acceptance speech, Dr. Ogbodo expressed profound gratitude for the recognition, stating that the award had deeply touched him and would further motivate his advocacy for peace and service to humanity.

“I am deeply humbled and honoured to receive this award,” he said. “It means a lot to me as it acknowledges contributions I never knew were being noticed. This recognition will further spur me to continue promoting peace, unity, and development.”

He urged fellow peace ambassadors to embody the values of integrity, neutrality, and positive engagement. “Tarnish no image. Blackmail no opponent. Build bridges across tribes, cultures, and political divides. Serve as true ambassadors of peace,” he urged.

Dr. Ogbodo pledged continued support for NANYAPI and reaffirmed his commitment to peacebuilding efforts across Nigeria.

The ceremony also featured goodwill messages from traditional leaders, security officers, youth leaders, and the hospital staff, including HRH Chief Mark Barron Onah, Ward Head of Akpodo Community; SP Okoliko, DPO of Ugbokolo Division; Hon. Andrew Ameh, Youth Leader of Amejo Ward; Inspector Ogbaka of Ugbokolo Police Division; and staff of Lydia Memorial Hospital.

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