Connect with us

Health

New TB Vaccine in 100 Years Advances as Welcome, Gates Foundation Fund Trial

Published

on

Share

Welcome and the Bill & Melinda Gates Foundation have announced funding, to advance a tuberculosis (TB) vaccine candidate, M72/AS01E (M72), through a Phase III clinical trial.

If proven effective, M72 could potentially become the first new vaccine to help prevent pulmonary TB, a form of active TB, in more than 100 years.

Wellcome and the Bill & Melinda Gates Foundation made the announcement at a virtual news conference on Wednesday.

The event featured Trevor Mundel, President of Global Health at the Gates Foundation; Alexander Pym, Director of Infectious Diseases at Wellcome; and Nomathamsanga Majozi, Head of Public Engagement at the Africa Health Research Institute.

The only TB vaccine in use today, Bacille Calmette-Guérin (BCG), was first given to people in 1921.

It helps protect babies and young children against severe systemic forms of TB but offers limited protection against pulmonary TB among adolescents and adults.

TB is one of the world’s deadliest diseases, killing about 4,300 people per day, mostly those living in poverty.

In 2021, an estimated 10.6 million people fell ill with TB and 1.6 million died—about 4,300 people per day.

The disease primarily affects people in low and middle income countries, and those at highest risk are often living in poverty, with poor living and working conditions and undernutrition.

Up to a quarter of the world’s population is thought to have latent TB, a condition in which a person is infected with the bacterium that causes TB but does not have any symptoms and is at risk of progressing to active TB disease.

To support the M72 Phase III clinical trial, which will cost an estimated US$550 million, Wellcome is providing up to US$150 million and the Gates Foundation will fund the remainder, about US$400 million.

The vaccine, called M72, will be given from Year 2024 to 26,000 young adults in Africa and south-east Asia who have a latent infection with the bacteria that cause TB but no symptoms.

Commenting on the efficacy, Trevor Mundel, the Head of Global Health at the Bill & Melinda Gates Foundation, said that M72 had shown much promise in preventing TB in people with latent infections, but were not ill.

This, he said, was an important segment of the population to target.

However, “clear evidence about M72’s efficacy in preventing the emergence of active pulmonary tuberculosis will take several years to emerge from trial.

“Of course we’d be happy with 90 per cent efficacy but from our modelling, 50 per cent is good enough on the assumption that the durability is at least five years.

“Most of the vaccinologists who have looked at the data have said that is likely”.

He said the trial would probably last for four to six years.

Speaking on affordability, he said making the vaccine as affordable and as accessible as possible would be very important.

Julia Gillard, Chair of the Board of Governors at Wellcome, said: “TB remains one of the world’s deadliest infectious diseases.

“The development of an affordable, accessible vaccine for adults and adolescents would be game-changing in turning the tide against TB.

“Philanthropy can be a catalyst to drive progress, as shown by this funding of the M72 vaccine as a potential new tool in preventing escalating infectious diseases to protect those most affected.

“Sustainable progress against TB and wider disease threats will depend on global collaboration, financial backing, and political will.

“By working with communities and researchers in countries with a high burden of the disease, we can get one step closer to eliminating TB as a public health threat.”

Nomathamsanqa Majozi, Head of Public Engagement at Africa Health Research Institute, said: “Despite being curable, TB remains one of the leading causes of death in South Africa.

“In the area where I live and work, more than half of all people have had, or will have TB at some points in their lives.

“The consequences are devastating, both at a personal and a community level. M72 offers us new hope for a TB-free future.’’

Alexander Pym, the Director of Infectious Disease at Wellcome, said TB was one of the biggest health challenges in the world.

“Treatment is still four to six months long. Diagnostics can still not diagnose early enough to prevent transmission.

“Added to that is the threat of latent TB.”

He said the human immune response to TB was much more complex than to an acute viral infection and this made the process of developing a TB vaccine much longer.

“The challenge is big. We need new approaches and tools,” he said.

According to Pym, a TB vaccine will really be a game-changer; there is a need for TB innovation.

Bill Gates, Co-chair of the Bill & Melinda Gates Foundation, commented in a joint statement by the organisations.

“With TB cases and deaths on the rise, the need for new tools has never been more urgent.

“Greater investment in safe and effective TB vaccines, alongside a suite of new diagnostics and treatments could transform TB care for millions of people, saving lives and lowering the burden of this devastating and costly disease.”

World Health Organisation (WHO) Director-General, Dr Tedros Adhanom Ghebreyesus, commended the support by the Gates Foundation and Wellcome to develop a new TB vaccine.

“WHO welcomes the commitments from the Bill & Melinda Gates Foundation and Wellcome to take forward development of this vaccine candidate.

“WHO will keep supporting vaccine development and access more broadly through its TB Vaccine Accelerator Council.” (NAN)

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Health

Anxiety Grips FCT Residents As FG Confirms Ebola Disease Case 

Published

on

Share

By Laide Akinboade, Abuja

The Federal Government (FG), on yesterday confirmed one case of Ebola disease in the Federal Capital Territory (FCT), following laboratory confirmation.

Minister of Health and Social Welfare, Prof.

Muhammad Ali Pate, stated this while briefing journalists in Abuja.

He said the patient, a woman, who was from Uganda, was admitted in Abuja and the diagnosis has been confirmed.

The statement reads, “The patient, a woman who recently arrived in Nigeria on an international flight from Uganda, was admitted to a private hospital in the FCT, where she received care for several days before the diagnosis was confirmed.

She is currently in isolation and receiving medical care.

“The Federal Minister of Health and Social Welfare and NCDC are working closely with the FCT Health Services Secretariat and other relevant authorities to contain the infection and prevent further spread..

“Contact tracing has commenced with 44 close contacts identified presently, with public health teams identifying and monitoring people who may have been exposed, including healthcare workers, patients, caregivers and travel contacts. Surveillance has been intensified, and the hospital is receiving immediate support to strengthen infection prevention and control measures.

“The FG calls on all public and private healthcare facilities nationwide to be on high alert. Healthcare workers must maintain a high index of suspicion, promptly identify and isolate suspected cases, observe strict infection prevention and control measures, and immediately report suspected cases to public health authorities.

“What Nigerians Should Know and Do

Ebola spreads through direct contact with the blood or body fluids of someone who is sick with the disease or has died from it, or through contact with contaminated materials. A person with Ebola cannot spread the disease before symptoms begin”.

The Federal Government therefore advised residents to remain calm but vigilant.

“Remain calm but vigilant. There is no need for panic. Practise regular hand hygiene and avoid contact with the body fluids of anyone suspected to have Ebola.

Watch for symptoms, including fever, severe weakness, headache, vomiting and diarrhoea, particularly following possible exposure.

“Report any possible exposure immediately, even if you feel well. If you develop symptoms, avoid close contact with others and call public health authorities for guidance before visiting a healthcare facility.

” Cooperate with public health teams. Anyone contacted during contact tracing, including relevant airline passengers, should provide the necessary information and follow public health advice.

“Avoid rumours and stigma. Share only verified information from official health authorities” .

The Minister recalled, “Our Assurance to Nigerians. Nigeria successfully contained Ebola in 2014, and we have the experience and public health systems to respond to this case. However, containing Ebola requires everyone to play their part.

“The Federal Government, FCT authorities and other partners are working together to protect healthcare workers, patients and the wider public. Investigations are ongoing, and we will continue to provide accurate and timely information.

” We urge Nigerians to remain calm, stay vigilant and cooperate with public health authorities. Early detection, prompt reporting and everyone’s cooperation are critical to preventing further spread.

“The Government of Nigeria through the Presidential Taskforce on EVD and NCDC will continue to provide updates.

NCDC free call centre is available 24 hours a day, seven days a week. For information or to report a suspected case, please call NCDC toll-free number 6232″.

Continue Reading

Health

Tuberculosis: Benue Assembly Passes Law, to Protect Patients from Discrimination

Published

on

Share

By Laide Akinboade, Abuja

The Benue State House of Assembly has passed into law a landmark legislation aimed at eliminating tuberculosis (TB) and protecting persons affected by the disease from discrimination and human-rights violations.

The legislation, known as the Tuberculosis Elimination, Human Rights Protection and Anti-Discrimination Law of Benue State, 2026, was passed into Law during Thursday plenary presided over by Speaker, Rt.

Hon.Berger Alfred Emberga, MNIQS, RQS, following consideration of the report of the House Standing Committee on Health and Human Services.

‎The committee, chaired by Hon. Matthew Damkor, Ph.D., said the legislation was necessary to provide a comprehensive legal framework for tuberculosis prevention, diagnosis, treatment, care and control across the state.

‎The law also seeks to safeguard the rights of persons affected by Tuberculosis (TB), including their rights to dignity, healthcare, privacy, information, employment, education and social protection.

‎In its report, the committee identified several areas of the original Bill that required amendment, particularly provisions relating to federal laws and institutions, implementation responsibilities, screening and isolation, enforcement mechanisms, offences and penalties.

‎The committee recommended the removal of provisions purporting to amend federal legislation, particularly the Employees’ Compensation Act, 2010, noting that such amendments were inappropriate for state legislation.

‎It also recommended that references to federal institutions as implementing authorities be replaced with relevant Benue State institutions, while allowing for lawful collaboration with federal authorities.

‎The committee further recommended that the Commissioner for Health and Human Services, through the Ministry of Health and relevant state agencies, be clearly designated to coordinate the implementation of the law.

‎On the protection of fundamental rights, the House called for clearer safeguards in provisions dealing with TB screening, isolation and restriction of movement, including informed consent, confidentiality, medical necessity, proportionality and the use of the least restrictive measures.

‎It also recommended the establishment of an accessible mechanism for receiving complaints, addressing discrimination and providing remedies to persons whose rights may have been violated under the law.

‎The House further urged relevant agencies to ensure that offences and penalties under the legislation are clearly defined, proportionate and enforceable.

After considering and adopting the committee’s recommendations clause-by-clause, the bill was read for the third time and subsequently passed into law by the Speaker, Rt. Hon. Emberga following a unanimous consideration and adoption by members.

‎The Tuberculosis Law which was sponsored by Hon. Dr. Simon Gabo of Mata State Constituency and others, is expected to strengthen Benue State’s response to tuberculosis and provide a stronger legal framework for protecting persons affected by the disease from stigmatization, discrimination and other rights violations.

‎Meanwhile, Civil Society Organisations, Lawyers Alert and Media Health and Rights Initiative of Nigeria, MHR, have commended the Benue State House of Assembly for taking steps to strengthen the state’s response to tuberculosis, and protect the rights of persons affected by the disease.

In a joint statement, the President of Lawyers Alert, Rommy Mom and the Executive of MHR, Alu Azege said the Bill brings health and human rights dimensions of TB into legislative conversation in the state.

Continue Reading

Health

Agency Seals 12 Islamic Medicine Stores, One Clinic in Niger Crackdown

Published

on

Share

The Niger State Private Health Facilities Agency (NiSPHFA) has sealed 12 unregistered Islamic medicine stores in Minna and a health facility in Katcha Local Government Area (LGA).

The Executive Chairman of NiSPHFA, Dr.

Abdullahi Suleiman, disclosed this while receiving members of the Islamic and Prophetic Medicine Practitioners’ Association of Nigeria (IPMPAN) in Minna.

The enforcement is part of the agency’s renewed efforts to protect residents from unsafe healthcare practices and ensure compliance with minimum standards.

Suleiman said the facilities were sealed over alleged non-compliance with regulatory standards.

According to him, the enforcement is not aimed at persecuting healthcare providers but at ensuring residents have access to safe, quality, and standard-compliant healthcare services.

“Our responsibility is to protect the people by ensuring that anyone providing healthcare services operates within the required standards,” he said.

He urged genuine alternative medicine practitioners to register with NiSPHFA, saying registration would enable the agency to identify operators, monitor their activities, and protect residents from unsafe products and practices.

Suleiman also announced plans to organise a trade fair for verified alternative medicine practitioners to promote legitimate practices and improve public confidence in alternative healthcare.

He emphasised the need for practitioners to maintain minimum standards of hygiene, sanitation, safe preparation and storage of medicines, proper packaging, and infection prevention.

“Practitioners should refer patients whose conditions are beyond their capacity to appropriate health facilities. Such referrals will help reduce avoidable health risks,” he said.

The chairman said sustained enforcement, stakeholder collaboration, and improved compliance would enable NiSPHFA to safeguard residents and promote a safer, more accountable, and quality-driven healthcare system across the state.

He said the NiSPHFA enforcement team inspected 10 health facilities in Katcha local government and identified various irregularities requiring improvement.

Suleiman said the affected facilities were issued 21-day notices to correct the identified deficiencies.

“One of the facilities inspected was sealed for non-compliance with established standards,” he said.

He added that the agency also secured the support of the local government area in identifying and addressing facilities operating with irregularities.

IPMPAN Chairman, Abdullahi Haske, commended the state government for establishing NiSPHFA.

He pledged the association’s cooperation in ensuring that its members complied with regulatory requirements.

Continue Reading

Advertisement

Top Stories

NEWS6 hours ago

Adeniyi, JAMB Registrar Seek Operational Synergy

ShareBy Tambaya Julius, Abuja The Nigeria Customs Service (NCS) and the Joint Admissions and Matriculation Board (JAMB) are considering areas...

NEWS6 hours ago

NLC Suspends FCT Indefinite Strike

ShareThe Nigeria Labour Congress (NLC), Federal Capital Territory (FCT) Council, has suspended its indefinite strike and directed all affected workers,...

NEWS6 hours ago

APC Dismisses Alleged Plot to Assassinate Atiku

ShareThe All Progressives Congress (APC) Presidential Campaign Council (PCC) has dismissed allegations that the Federal Government is plotting to assassinate...

NEWS6 hours ago

2027: We’ll Deliver Rivers, FCT for Tinubu – Wike

ShareBy Laide Akinboade, Abuja The Minister of the Federal Capital Territory (FCT), Nyesom Wike, has declared that the All Progressives...

NEWS7 hours ago

Tinubu’s Three Bills and the Burden of Government

ShareBy Tom Chiahemen A government that asks its citizens to endure the pain of economic reform must demonstrate a corresponding...

NEWS7 hours ago

DMO Raises N2.02trn As FGN Bond Yields Rise To 17.29 Per Cent

ShareBy Tony Obiechina, Abuja Yields on Federal Government of Nigeria (FGN) bonds increased by as much as 50 basis points...

Health7 hours ago

Anxiety Grips FCT Residents As FG Confirms Ebola Disease Case 

ShareBy Laide Akinboade, Abuja The Federal Government (FG), on yesterday confirmed one case of Ebola disease in the Federal Capital...

NEWS7 hours ago

Again, Tinubu Rules Out Return to Petrol Subsidy Regime

ShareBy Tambaya Julius, Abuja President Bola Ahmed Tinubu has ruled out a return to petrol subsidy, insisting that his administration...

NEWS1 day ago

Former Delta Governor Uduaghan Dies at 70

ShareFrom Francis Sadhere, Delta Former Governor of Delta State, Dr. Emmanuel Eweta Uduaghan, has died. Uduaghan, who governed the state...

NEWS1 day ago

Customs Opens Review for Disqualified Recruits, Flags 397 Applicants

ShareBy Tambaya Julius, Abuja The Nigeria Customs Service (NCS) has opened a review process for applicants disqualified during its recent...